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Nordic Nutrition Recommendations 2012 - Livsmedelsverket

The SLC10A transporter gene family consists of seven members and substrates transported by three members (SLC10A1, SLC10A2 and SLC10A6) are Na +-dependent. SLC10A1 (sodium taurocholate cotransporting polypeptide [NTCP]) and SLC10A2 (apical sodium-dependent bile salt transporter [ASBT]) transport bile salts and play an important role in maintaining enterohepatic circulation of bile salts. Na+-dependent bile salt transport system in the hepatocytes of the adult lamprey, with a very low affinity for TCA (K m = 115 ± 8.7 µM). This is strikingly different from previous observations in isolated hepatocytes from skate and rainbow trout1,2 that appear to lack a Na+-dependent TCA transporter. 2000-04-01 · In addition to sodium/bile salt cotransport, sodium-independent bile salt transport pathways are also present at the basolateral plasma membranes of hepatocytes (8, 9, 11). These sodium-independent bile salt uptake systems have been less well characterized compared with the sodium-coupled uptake carrier, a fact that is reflected by the broad range of reported apparent K m values between 9 and However, both stomatin overexpression and knockdown increased NTCP-mediated taurocholate uptake while NTCP abundance at the plasma membrane was only increased in stomatin depleted cells.

Na bile salt cotransport

Na -independent bile salt uptake is mediated by the multispeciﬁc organic anion transporting polypeptides OATP-A The Na(+)-taurocholate cotransporting polypeptides Ntcp and NTCP mediate strictly Na(+)-dependent bile salt uptake into rat and human hepatocytes, respectively. Extensive characterization of Ntcp expression and function in a variety of eukaryotic cell lines, cultured hepatocytes, and intact rat liver indicates that Ntcp can account for most, if not all, Na(+)-dependent bile salt transport Bile salt transport profiling of hepatic transporters Peter Krajcsi. The human bile Carey and Duane: The liver, 3rd edition. Bile acids / salts Primary bile acids: Chenodeoxycholic acid Cholic acids Secondary bile acids: Lithocholic acid Deoxycholic acid Ursodeoxycholic acid Cholesterol Saltis Transport AB,559064-3424 - På allabolag.se hittar du , bokslut, nyckeltal, styrelse, Status, adress mm för Saltis Transport AB The sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the basolateral membrane of hepatocytes, where it mediates the uptake of conjugated bile acids and forms the hepatocyte entry receptor for the hepatitis B and D virus. Here, we aimed to identify novel protein–protein interactions that could play a role in the regulation of NTCP. To this end, NTCP was precipitated 2021-01-20 Sodium/bile acid cotransporter also known as the Na + - taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.

Epclusa - FASS Allmänhet

Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypept …. Bile salts are the major organic solutes in It has been proposed that the hepatocellular Na (+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes.

Anna Casselbrant Göteborgs universitet

u 1987 Academic Press, Inc. Bile salts are reabsorbed in proximal tubules of rat kidney against a concentration gradient by a Na+-dependent transport system (1). The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport. 23,24 There is evidence that hepatocyte entry may be a multistep process including binding to heparan sulfate ASBT is Na-dependent uptake transporter of bile acids and conjugates. It has an important physiological function as the first step in bile acid (BA) reabsorption from the intestine, playing a key role in the enterohepatic recirculation of BAs [1].

How to abbreviate Na(+)-bile Salt Co-transporter? Get the most popular abbreviation for Na(+)-bile Salt Co-transporter updated in 2021 bile salt carriers, membranelipid compositionandflu-idity are also majordeterminants of bile salt excretion (15, 16). These associations have suggested the hy-pothesis that alterations in either specific bile salt re-ceptors or membranelipid composition are important determinants of maximum bile salt transport. How-ever, these correlations have ABCB11, a bile salt export pump, has been identified as the major canalicular bile salt-transporting protein, and the mutations in ABCB11 cause progressive familial intrahepatic cholestasis 2 [69]. It was revealed that knockout of PPARα decreases hepatic ABCB11 levels in mice, leading to the accumulation of bile acids in the liver following cholic acid dietary challenge [40] .
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Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans). The SLC10A transporter gene family consists of seven members and substrates transported by three members (SLC10A1, SLC10A2 and SLC10A6) are Na +-dependent.

1 ways to abbreviate Na(+)-bile Salt Co-transporter. How to abbreviate Na(+)-bile Salt Co-transporter? Get the most popular abbreviation for Na(+)-bile Salt Co-transporter updated in 2021 1992-08-01 The Na+/bile salt co-transporter of the pig ileal brush border membrane has been expressed in Xenopus laevis oocytes.
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Kompendium GI. I-III Homeostas HT-15 Jonas Liefke

Human NTCP contains 349 amino acids and has a mass of 56 kDa. Function. Bile acid:sodium symporters participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids.

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"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer

Injection of pig ileal poly (A)+ RNA into oocytes resulted in the functional expression of an Na(+)-gradient-stimulated taurocholate uptake within 2-5 days. The expressed Na(+)-dependent taurocholate uptake exhibited saturation kinetics (apparent Km of 48 microM), and displayed 2021-04-01 · The reuptake of bile salts by the SLC10A1 transporter concludes the enterohepatic cycle of bile salt circulation (summary by Vaz et al., 2015). Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. 12 Nov 1997 dent bile salt uptake, the physiological and biochemical proper-.

e-spik Irina - Lund University

The importance of membrane voltage in uptake of bile salts into hepatocytes is not known. Electrogenicity of the primary bile salt transport process, Na-bile salt cotransport, has been difficult to determine because the large K and Cl conductances of the sinusoidal membrane (GK and GCl, respectively) obscure any transport associated currents. Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation.

NKCC2 is found The system operates by a sodium ion cotransport mechanism, and it functions in maintaining a normal enterohepatic circulation of bile salts. Analysis of structure-activity data allows us to depict our hypothesis for the interaction of bile salt and Na with the membranal recognition site of this transport system. the SLC10 sodium bile salt cotransporters Na+/taurocholate cotransporting polypeptide (NTCP) and the apical sodium-dependent bile salt transporter (ASBT). While expression of NTCP is restricted to The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts.